Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC)


It consists in the intracavitary nebulization, with laparoscopic technique, of chemotherapeutic drugs in order to increase intracellular and interstitial penetration, enhancing the activity with dosage reduction.

The current scientific literature attests that the PIPAC technique offers good results and is a safe method for the treatment of peritoneal carcinosis in patients on whom you cannot intervene with traditional surgical removal.


PIPAC treatments (Pressurized IntraPeritoneal Aerosol Chemotherapy) allow to use a minimal amount of chemotherapy compared to systemic therapies. 

The average duration of treatment is about 30 minutes.

How does the PIPAC technique work?

PIPAC is the nebulization of drugs through CapnoPen ™ (micro-atomizer in medical steel), inserted with a laparoscopic trocar. This technique allows simultaneous execution of any biopsies or aspiration of the ascitic fluid. 

The PIPAC Objective?

The aim of PIPAC is to permeate all endocavitary surfaces with nebulised aerosol, also involving spaces otherwise difficult to reach. The laparoscopic technique allows to evaluate the spread of carcinosis and to control its pharmacological impregnation during the procedure. 

PIPAC is therefore indicated in the palliative treatment of carcinoses, especially those with refractory ascites and neoadjuvant for patients not currently eligible for surgery (debulking).


What are PIPAC advantages?

The main advantages are:

- minor side effects typical of systemic chemotherapy

- repeatability of the procedure

- low invasiveness

- monitoring of the response to local chemotherapy, through biopsies




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