We are happy to congratulate Gregg L. Semenza, William G. Kaelin Jr., Sir Peter J. Ratcliffe – our colleagues in the area of hypoxia research, with the highest scientific achievement: the Nobel Prize in Physiology or Medicine!



ReOxy®is a new breathing therapy medical device, that treats a patient with individually dosed levels of reduced-oxygen (hypoxic) gas mixtures throughout the procedure.

The main objective to be achieved with use of the ReOxy device is short and long-term adaptive response at systemic, organic, tissue and cellular levels. These compensatory mechanisms of adaptation have been scientifically proven to effectively treat cardiovascular and metabolic diseases.

ReOxy uses Self Regulated Treatment (SRT®) technology. SRT‑technology relies upon the principle of biological feedback, where patient bodily reaction define therapeutic parameters and controls them throughout the whole treatment session.

ReOxy Technology


SRT Technology
SRT uses advanced software that reads and analyses information from a built-in pulse oximeter to adjust the supplied air mixture and timing for each patient individually in response to changes in vital indicators, i.e. blood oxygen saturation (Sp02) and heart rate.

Tecnologia SRT


Usage of innovative SRT-Technology allows:

  • Pre-treatment test – to evaluate zone of maximal therapeutic efficacy and to calculate individual treatment parameters;
  • Treatment – to “keep” the patient in zone of maximal therapeutic efficacy by adjusting the treatment parameters in response to changes in patients state;
  • After the treatment – to calculate and store treatment parameters for the next treatment session;

Interval Hypoxic Treatment

Interval Hypoxic Treatment (IHT) consists of repeated shortterm hypoxia (9-15% O2), interrupted by brief periods of recovery. These periods of recovery could be either normoxic (21% O2, Hypoxia-Normoxia mode), or hyperoxic (30-35% O2, Hypoxia-Hyperoxia mode). Typical treatment course comprises 10-15 sessions.

Vantaggi IHHT


Clinical Effects of IHT

  • Long-lasting antihypertensive effects [1, 2, 9, 19, 23, 24, 29] IHT reduced BP, improved the patients’ health status and physical performance, and normalized O2 consumption and transport. The antihypertensive effect persisted for 6 months in 80% and for 1 year in 43% of the patients. Seventy-nine percent of these patients were able to discontinue medications after IHT. No unfavorable effects were observed [19].
  • Increases exercise workload tolerance [1, 7, 8, 9, 11, 15, 16, 17, 21, 29] Low exercise tolerance contributes to mortality in patients with coronary artery disease (CAD) and chronic obstructive pulmonary disease (COPD). Interval hypoxia might be a valuable preventive and therapeutic tool for these patients [4].
  • Increase of myocardial tolerance to hypoxia/ischaemia (cardioprotective and antianginal effects) IHT produced robust antianginal effects in patients with ischemic heart disease. These effects persisted for 3 months after IHT therapy in 88% of patients and for 6 months in 80% of patients [6,9, 19].
  • Increase of myocardial vascularity, coronary blood flow (neoangiogenesis – collateral capillaries outgrowth, endothelium-dependent vasodilatation) [3, 33, 35]
  • Metabolic effect
    Moderate IH protocols are reported to have beneficial effects on metabolism, including reduced body weight, cholesterol and blood sugar levels, and insulin sensitivity [25].
    - Normalises cholesterol levels, decreases LDL and triglycerides, increases HDL [5, 7, 9, 13, 14, 20, 27, 31]
    - Hypoglycaemic effect [5, 7, 31]
    - Increases body weight loss [11, 12, 32]
    - Suppresses the appetite [32, 34]
  • Other effects
    - Significant improvement in quality of life [30]
    - Short-term memory and cognitive performance improvement [30]
    - Reduction of endothelial injury and dysfunction [10]

Indications for IHT
Cardiovascular diseases:

  • Arterial Hypertension
  • Ischaemic Heart Disease
Metabolic disorders:

  • Obesity
  • Metabolic Syndrome
Further Applications:

  • Rehabilitation after Myocardial Infarction and cardiac surgery
  • Chronic Heart Failure (in research)
  • Rehabilitation after Chronical Spinal Cord Injury




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